Volta

Dynamic change and spatial distribution of HIV-1 CRF119_0107 transmission clusters from 2019 to 2024 in Nanjing, China: a genomic and spatial epidemiological analysis

<title>Abstract</title> Background Since its initial detection among men who have sex with men (MSM) in Nanjing, CRF119_0107 has rapidly emerged as the third most prevalent HIV-1 subtype. To elucidate its transmission dynamic change, spatial characteristics, and transmitted drug resistance (TDR) prevalence, we conducted a joint analysis of genomic and spatial epidemiology. Methods From 2019 to 2024, a total of 138 antiretroviral therapy (ART)-naïve individuals newly diagnosed with HIV-1 CRF119_0107 infection were enrolled. HIV-1 <italic>pol</italic> gene sequence was obtained by viral RNA extraction and nested PCR. Molecular transmission network was constructed using HIV-TRACE while spatial distribution analyses were performed in ArcGIS. Multivariate logistic regression was used to analyze the factors associated with clustering. The transmission links of the network was visualized …

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