Volta

Ebola Virus Disease, Vaccines, Therapeutics, Transmission, and Long-Term Sequelae: Scoping Review with ☸SAIMSARA

To map and synthesize the original research evidence on Ebola virus disease, including clinical presentation and prognosis, transmission and outbreak control, diagnostics, vaccines, therapeutics, pathophysiology, survivor sequelae, health-system effects, and implementation challenges. The review uses 810 references and builds its evidence map from 2251 original studies with 4785212 total participants/sample observations (topic-deduplicated ΣN). This scoping review indicates that Ebola virus disease outcomes are consistently shaped by viral load, age, organ dysfunction, and the timeliness of effective care, with case fatality reaching 62.9% across the 2013–2016 West African epidemic and exceeding 80% in children under five years and older adults. The evidence supports a role for rVSV-ZEBOV vaccination in reducing both infection risk and mortality among confirmed cases, while monoclonal antibody …

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