Volta

The Gut–Brain Axis and Peroxisome Proliferator-Activated Receptors in the Regulation of Epileptogenesis

Abstract A large proportion of patients with epilepsy suffer from pharmacoresistant forms of the disease, and this makes the search for new treatments urgent. The possible role of gut–brain interactions in the pathogenesis of epilepsy is widely discussed. Recent experimental and clinical studies show a correlation between gut microbiota balance and epileptogenesis severity. Besides, various methods of modifying the microbiota composition demonstrate its significant impact on the clinical course of epilepsy. Nevertheless, the question remains open as to the basic receptor link of the gut–brain axis, which is an interface between the gut microorganisms and the body’s regulatory systems. This review aims to analyze the pathways and levels of gut microbiota involvement in epilepsy pathogenesis and recovery from this disease. …

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