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Electrophysiological sexual dimorphism as an early risk marker of alcohol use in adolescence: A longitudinal neuroimaging study

AIMS: To identify the brain activity profiles associated with alcohol consumption and to address its causes. Furthermore, we sought to examine the relationship between these electrophysiological markers and the excitation-inhibition balance, as well as to explore the potential moderating role of sex in these associations. DESIGN: Longitudinal study involving a neuroimaging assessment that included magnetoencephalography (MEG) and magnetic resonance imaging (MRI), along with a battery of self-report questionnaires. A follow-up assessment was conducted two years later using the same set of neuroimaging and behavioural measures. SETTING AND PARTICIPANTS: 56 adolescents aged 13 to 17 years recruited from high schools in the community of Madrid, Spain, prior to the initiation of alcohol use. MEASUREMENTS: We extracted measures of power spectral density …

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