Volta

Rethinking chemical hazard: an AOP-guided approach to non-conventional endpoints in the environmental assessment of neurotoxic, immunotoxic and metabolic toxic compounds

Abstract Chemical pollution is identified as a significant driver of biodiversity loss, raising concerns about the effectiveness of current environmental risk assessment (ERA) practices. Conventional ERA approaches primarily rely on the endpoints of mortality, growth, and reproduction, often failing to capture the full scope of potential effects that chemicals can have on organisms. This is potentially problematic in cases of chemicals causing neurotoxicity, immunotoxicity, and metabolic toxicity, which have recently been introduced to the discussion under REACH by the new report of the European Chemical Agency (ECHA) on Key Areas of Regulatory Challenge . For these modes of action (MoAs), which have to date been discussed primarily in the context of human toxicity, there is currently no established approach for …

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