Volta

Early detection of SARS-CoV-2 variants using genomic surveillance: insights from aircraft wastewater and nasal swabs at Kigali International Airport, Rwanda

Objectives: The growing threat of emerging infectious diseases necessitates proactive genomic surveillance, particularly, in regions with limited resources and low levels of existing reporting. This study highlights the implementation of a comprehensive genomic surveillance program at the Kigali International Airport and explores the utility of a dual-sample strategy leveraging environmental aircraft wastewater and pooled nasal swab sample types for comprehensive detection and characterization of SARS-CoV-2 lineages being imported into Rwanda. Methods: Using a combined pooled nasal swab and aircraft wastewater sampling approach resulted in complementary insights in terms of geographic coverage, positivity, and variant characterization. Results: Mutational profiling in source pooled nasal swabs and aircraft wastewater sample data revealed dynamic shifts in mutation prevalence that corresponded with global patterns. Emerging …

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