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Characterization of two novel HIV-1 recombinant forms (CRF01_AE/B and C/B/CRF01_AE) Among Men Who Have Sex with Men in Hebei Province, China

Abstract In recent years, many new circulating recombinant forms (CRFs) and unique recombinant forms (URFs) of human immunodeficiency virus type one (HIV-1) have been discovered among men who have sex with men (MSM) in China. In this study, we report two HIV-1 URFs (BDL154 and BDL161) identified in the MSM population in Hebei Province, China. The phylogenetic tree and recombination analysis based on the near-full-length genome (NFLG) sequences showed that BDL154 was a recombination form originated from CRF01_AE and subtype B, whereas BDL161 consisted of subtypes C ,B and CRF01_AE. BDL154 and BDL161 contained three and eight fragments, respectively. The analysis of recombination breakpoints showed that the recombination pattern of BDL154 sequence was the insertion of one B gene fragment …

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