Volta

Molecular characterization of a unique Recombinant form of HIV-1 subtype F2/CRF02_AG identified in Guangdong, China

BACKGROUND: The human immunodeficiency virus type 1 (HIV-1) pandemic continues to pose a significant global public health challenge. Recombination between HIV-1 variants generates unique recombinant forms (URFs) and then circulating recombinant forms (CRFs) after ongoing transmission. Subtype F2 and CRF02_AG mainly spread in western Africa, but they are rarely detected in China. Here, we observed a URF composed of subtypes F2 and CRF02_AG isolated from a man (230794) in Guangdong, China. METHODS: The near full-length genome (NFLG) of HIV-1 was amplified with two overlapping segments by the near endpoint dilution method. The positive products were sequenced directly to obtain genomic sequences. The recombinant pattern and breakpoints of the NFLG were determined using the Simplot software and confirmed by maximum likelihood …

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