Volta

Parental Cardiovascular Disease as a Risk Factor for Cardiovascular Disease in Middle-aged Adults

CONTEXT: Whether parental cardiovascular disease confers increased risk independent of other risk factors remains controversial. Prior studies relied on offspring report, without complete validation of parental events. OBJECTIVE: To determine whether parental cardiovascular disease predicts offspring events independent of traditional risk factors, using a prospective design for both parents and offspring, and uniform criteria to validate events. DESIGN: Inception cohort study. SETTING: Framingham Heart Study, a US population-based epidemiologic cohort begun in 1948 with the offspring cohort established in 1971. PARTICIPANTS: All Framingham Offspring Study participants (aged > or =30 years) who were free of cardiovascular disease and both parents in the original Framingham cohort. MAIN OUTCOME MEASURES: We examined the association of parental cardiovascular disease with 8-year risk of …

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