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Sequence Notes: Characterization of the Near-Full-Length Genome of Two Novel Unique Recombinant Genome (CRF01_AE/CRF79_0107, CRF01_AE/CRF07_BC) in Hebei, China

The global fight against human immunodeficiency virus (HIV) is complicated by its extensive genetic diversity, which arises from high mutation rates, rapid replication, and frequent recombination events. These factors lead to the emergence of numerous recombinant forms of HIV-1, contributing to the virus's adaptability and complicating prevention and treatment efforts. In this study, we identified two novel, unique recombinant forms (URFs) of HIV-1, CRF01_AE/CRF79_0107 and CRF01_AE/CRF07_BC, through near full-length genome sequence analysis. These URFs were detected in two individuals within the student men who have sex with men (MSM) population of Shijiazhuang, Hebei Province, China. Both utilized CRF01_AE as the underlying template, and PQ585802 represents a second-generation recombinant form comprising CRF01_AE and CRF79_0107. It is a novel recombinant form that …

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