Volta

Performance of SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing and self-sampling in comparison to molecular and professional-use antigen tests: A systematic review and meta-analysis

Abstract Purpose Self-testing is an effective tool to bridge the testing gap for several infectious diseases; however, its performance in detecting SARS-CoV-2 using antigen-detection rapid diagnostic tests (Ag-RDTs) has not been systematically reviewed. To inform WHO guideline development, we evaluated the accuracy of COVID-19 self-testing and/or self-sampling using Ag-RDTs. Methods: We searched multiple databases for articles evaluating the accuracy of COVID-19 self-testing or self-sampling through November 7th, 2022. Cohen’s kappa was estimated to assess concordance between self-testing/self-sampling and fully professional-use Ag-RDT results. Bivariate meta-analysis was performed to obtain pooled performance estimates compared to molecular testing. The QUADAS-2 and GRADE tools were used to evaluate quality and certainty of evidence. Results: Among 43 studies included in the review, twelve reported on …

Reference & gravity metrics

Secondary-market trade history

References (0)

Cited by (1)