Volta

Metabolic dysbiosis as a predictor of immunological non-response among people living with HIV

Introduction: The molecular mechanisms of immunological non-response in people living with HIV (PLWH) on antiretroviral therapy (ART) remain unclear. This study aimed to identify baseline metabolic and cytokine profiles that differ between immunological responders (IR) and immunological non-responders (INR), thereby exploring early molecular features associated with this discordant outcome. Methods: A cohort of PLWH was established at Guangzhou Eighth People's Hospital during November-December 2023. Following a minimum of four years on ART, participants were classified as INR (CD4+ T cell count < 350 cells/μL) or IR (≥350 cells/μL). Baseline plasma metabolites and cytokines were quantified using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS) and the Olink multiplex proximity extension assay (PEA), respectively. Results: A total of 101 PLWH were enrolled, comprising …

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