Volta

Using machine learning methods to investigate the impact of comorbidities and clinical indicators on the mortality rate of COVID-19

Background: This study aims to develop a machine learning model to predict the 30-day mortality risk of hospitalized COVID-19 patients while leveraging federated learning to enhance data privacy and expand the model's applicability. Additionally, SHapley Additive exPlanations (SHAP) values were utilized to assess the impact of comorbidities on mortality. Methods: A retrospective analysis was conducted on 6,321 clinical records of hospitalized COVID-19 patients between January 2021 and October 2022. After excluding cases involving patients under 18 years of age and non-Omicron infections, a total of 4,081 records were analyzed. Key features included three demographic data, six vital signs at admission, and 79 underlying comorbidities. Four machine learning models were compared, including Lasso, Random Forest, XGBoost, and TabNet, with XGBoost demonstrating …

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