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Inference and forecasting phase shift regime of COVID-19 sub-lineages with a Markov-switching model

ABSTRACT The occurrences and domination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are still crucial factors for determining the coronavirus disease 19 (COVID-19) policies. We collected weekly Phylogenetic Assignment of Named Global Outbreak sub-lineages, naming genetically distinct lineages of SARS-CoV-2, including variants of concern, in the United Kingdom, South Africa, South Korea, Denmark, Germany, the United States, and worldwide. This study included 12,296,756 samples of the max share of the sub-lineages from the 33rd week of 2020 to the 40th week of 2022. This study conducted a two-state Markov-switching model to estimate the probability of the phase shift state and predicted the probability of each regime with the Hamilton filter and Kim’s smoothing algorithm. We discovered different weekly …

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