Volta

Evaluating the effectiveness of international travel controls to identify MPXV-infected travelers: a simulation study

BACKGROUND: In August 2024, the World Health Organization (WHO) declared a public health emergency due to the rapid spread of mpox in Africa and beyond. International travel controls (ITCs), such as health screening and viral testing, could help avoid/delay the global spread of MPXV, fostering preparedness and response efforts. However, it is not clear whether the viral tests at immigration are sufficient to avoid introduction of MPXV and which samples should be used on the viral tests. METHODS: We conducted a simulation study using epidemiological and viral load data to assess the effectiveness of health screening and polymerase chain reaction (PCR) testing at immigration. The primary outcome was the proportion of MPXV-infected travelers identified under various international travel control policies. …

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