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Molecular transmission network and drug resistance analysis of 404 HIV-1 cases infected through commercial heterosexual contact (2020–2024)

Background: HIV/AIDS remains a significant public health challenge. This study aimed to investigate the molecular transmission network and drug resistance characteristics among HIV-1 infected individuals through commercial heterosexual contact in Yubei District which located in a southwest city in China, thereby assessing HIV transmission risks in the region. Methods: Blood samples were collected from newly diagnosed HIV-1 patients in Yubei District in Chongqing city between 2020 and 2024, all of whom acquired the infection through commercial heterosexual contact. The HIV-1 pol region was amplified and sequenced to construct a phylogenetic tree. Drug resistance mutation sites were obtained by comparing with the Stanford Drug Resistance database. A molecular transmission network was constructed using a genetic distance threshold of 1.3%. Univariate and …

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