Volta

Comparison of clinical characteristics in acute and early HIV-1 infection across different subtypes: a hospital-based cohort study

Background: Early diagnosis and immediate antiretroviral therapy (ART) for acute and early HIV-1 infection (AEHI) effectively curb HIV transmission and restrict viral reservoir formation. However, subtype-specific transmitted drug resistance (TDR) and early ART virological response remain insufficiently characterized among circulating HIV-1 recombinants in the Guangdong-Hong Kong-Macao Greater Bay Area. This study aimed to compare these key indicators across different HIV-1 subtypes. Methods: This hospital-based cohort study enrolled 105 AEHI patients from 2019 to 2024. HIV-1 pol gene sequencing was performed for subtype classification and drug resistance genotyping. Antiretroviral therapy responses were monitored at weeks 4, 12, 24, and 48. Demographic, clinical, virological, immunological, and TDR data were systematically analyzed across all HIV-1 subtypes. Results: < 0.001), dominated by V179E and …

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