Volta

The Molecular Epidemiological and Immunological Characteristics of HIV-1 CRF01_AE/B Recombinants in Nanjing, China

[] · Frontiers in Microbiology · 2022
hash_id: 76b96a172550e3abf12dd95707c82706b5a6172c23a93b909357b727e5ee2042 · DOI: 10.3389/fmicb.2022.936502

Human immunodeficiency virus-type 1 (HIV-1) CRF01_AE/B recombinants are newly emerging strains that are spreading rapidly in Southern and Eastern China. This study aimed to elucidate the molecular epidemiological characteristics of HIV-1 CRF01_AE/B recombinants in Nanjing and to explore the impact of these novel strains on the immunological status. A total of 1,013 blood samples from newly diagnosed HIV-1-infected patients were collected in Nanjing from 2015 to 2019, among which 958 partial Pol sequences were sequenced successfully. We depicted the molecular epidemiological characteristics of CRF01_AE/B recombinants by the molecular evolutionary analysis, Bayesian system evolution analysis, and transmission network analysis. The generalized additive mixed model was applied to evaluate the CD4 + T-cell count change of CRF01_AE/B recombinants. The Kaplan–Meier analysis was …

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References (11)

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Near-Full-Length Genomic Characterization of Two Novel HIV-1 Unique Recombinant… primary
Molecular transmission network analysis of newly diagnosed HIV-1 infections in … primary
Co-receptor usage in distinct phylogenetic clusters of HIV-1 CRF01_AE is associ… primary
Comparison of clinical characteristics in acute and early HIV-1 infection acros… primary
Development and spatial validation of a prognostic model for poor immune recons… primary

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